8X SHAMPOO SIDE EFFECTS
Application site reactions (burning, irritation, itching and redness)
HOW TO USE 8X SHAMPOO
Use it as advised by your doctor or check the label for directions before use.
HOW 8X SHAMPOO WORKS
8X Shampoo is a combination of two antifungal medicines: Ciclopirox and Zinc pyrithione which treat dandruff. These medicines work by stopping the growth of fungi that cause dandruff by preventing them from forming their own protective covering.
Pharmacology
Pharmacodynamics
Ciclopirox is a hydroxypyridone antifungal agent, although the relevance of this property for the indication of seborrhoeic dermatitis is not known. Ciclopirox acts by chelation of polyvalent cations (Fe3+ or Al3+), resulting in the inhibition of the metal-dependent enzymes that are responsible for the degradation of peroxides within the fungal cell. Zinc pyrithione is known to have both a non-specific keratolytic and antifungal activities. Thus it is effective in the treatment of seborrhoeic dermatitis and dandruff. Ciclopirox/zinc pyrithione combination has a synergistic effect on the growth control and the reduction of Malassezia population. Aloe vera acts as a natural conditioner.
Pharmacokinetics
In a study in patients with seborrhoeic dermatitis of the scalp, application of 5 mL ciclopirox shampoo 1% twice weekly for 4 weeks, with an exposure time of 3 minutes per application, resulted in detectable serum concentrations of ciclopirox in 6 out of 18 patients. The serum concentrations measured throughout the dosing interval on days 1 and 29 ranged from 10.3 ng/mL to 13.2 ng/mL. Total urinary excretion of ciclopirox was less than 0.5% of the administered dose.
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